漢康生技（HanchorBio, KY-7827）宣布，其以自主 FBDB™ 多功能融合蛋白平台 開發的 三靶點創新藥 HCB301，已完成臨床一期前兩個劑量組安全性觀察，結果顯示耐受性良好，具臨床開發潛力。HCB301 兼具阻斷 SIRPα-CD47、PD-1/PD-L1 及 TGFβ 三大機制，能同時啟動先天與適應性免疫、克服腫瘤免疫抑制，為難治型癌症帶來新療法。該試驗（NCT06487624）正於中美兩地進行，台灣審查中，顯示漢康在免疫融合蛋白領域的全球開發邁出重要一步。

Novel fusion protein shows potent macrophage activation […]

全球臨床階段生技公司漢康生技（7827）宣布，旗下免疫治療新藥HCB101在臨床試驗中再度傳來捷報。繼二線胃癌 […]

全球臨床階段生技公司漢康生技（7827）公布旗下免疫治療新藥 HCB101 的最新臨床試驗數據，顯示該藥在晚期 […]

Prestigious peer-review validates HCB101’s differ […]

HanchorBio announced the successful completion of its latest Scientific Advisory Board (SAB) meeting. Chaired by Professor Mingyi Chen (UT Southwestern Medical Center), the SAB brings together global leaders from institutions such as The Ohio State University, University of Michigan, Tsinghua University, and National Taiwan University to review HanchorBio’s clinical progress, translational insights, and pipeline strategy across oncology and autoimmune diseases.

HanchorBio announced the successful completion of its latest Scientific Advisory Board (SAB) meeting. Chaired by Professor Mingyi Chen (UT Southwestern Medical Center), the SAB brings together global leaders from institutions such as The Ohio State University, University of Michigan, Tsinghua University, and National Taiwan University to review HanchorBio’s clinical progress, translational insights, and pipeline strategy across oncology and autoimmune diseases.

Showcase the Broad Therapeutic Potential of HCB101 in Tumor Immunotherapy *As the only innovative drug company from Taiwan invited to this year’s CBA Annual Conference, HanchorBio took the international stage to present its AI-assisted Structural Engineering on SIRP-alfa fusion biologic for enhancing Safety and Efficacy, marking an important milestone for Taiwan’s biotech industry.” *This recognition not only strengthens Taiwan’s position in global AI-assisted drug development, but also opens new opportunities for cross-border licensing and collaboration.

HanchorBio Inc. (7827.TWO), a global clinical-stage biotechnology company developing innovative immunotherapies for oncology and autoimmune diseases, today announced that the Taiwan Food and Drug Administration (TFDA) has approved a third investigator-initiated trial (IIT) evaluating HCB101 in combination with zolbetuximab and chemotherapy for the first-line treatment of patients with HER2-negative, CLDN18.2-positive advanced or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma.

HCB303 is a novel fusion protein designed to target multiple major immunosuppressive pathways, including PD-L1/PD-1, SIRPα/CD47, and others. By engaging both innate and adaptive immunity, it aims to enhance immune activation within the tumor microenvironment, driving T cell activation, NK cell cytotoxicity, and macrophage phagocytosis. HCB303 is currently in process development, with an IND submission planned by 2026, marking a key milestone in HanchorBio’s multi-target immunotherapy strategy to deliver breakthrough options for patients with refractory cancers.