{"id":2193,"date":"2026-01-05T19:30:13","date_gmt":"2026-01-05T11:30:13","guid":{"rendered":"https:\/\/www.hanchorbio.com\/news\/asco-gi-2026\/"},"modified":"2026-01-06T11:06:10","modified_gmt":"2026-01-06T03:06:10","slug":"asco-gi-2026","status":"publish","type":"news","link":"https:\/\/www.hanchorbio.com\/zh-hans\/news\/asco-gi-2026\/","title":{"rendered":"\u6c49\u5eb7\u751f\u6280\u5c06\u4e8eASCO\u6d88\u5316\u9053\u80bf\u7624\u5927\u4f1a2026 \u53d1\u5e03 HCB101 \u8054\u5408\u6807\u51c6\u6cbb\u7597\u5728\u7b2c\u4e8c\u7ebf\u80c3\u764c\u4e2d\u7684\u65e9\u671f\u4e34\u5e8a\u7ed3\u679c"},"content":{"rendered":"

\u6c49\u5eb7\u751f\u6280\u5c06\u4e8e<\/strong>ASCO<\/strong>\u6d88\u5316\u9053\u80bf\u7624\u5927\u4f1a<\/strong>2026 <\/strong>\u53d1<\/strong>\u5e03<\/strong> HCB101 <\/strong>\u8054<\/strong>\u5408\u6807\u51c6\u6cbb\u7597<\/strong>\u5728<\/strong>\u7b2c\u4e8c\u7ebf\u80c3\u764c<\/strong>\u4e2d\u7684<\/strong>\u65e9\u671f\u4e34\u5e8a<\/strong>\u7ed3\u679c<\/strong><\/h2>\n

\u5242\u91cf\u76f8<\/em>\u8d56\u6027<\/em>\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u652f\u6301<\/em> HCB101 <\/em>\u4f5c<\/em>\u4e3a\u53ef\u4e0e\u7b2c\u4e8c\u7ebf\u80c3\u764c\u6807\u51c6\u6cbb\u7597<\/em>\u534f\u540c\u5e94\u7528<\/em>\u7684\u5148\u5929\u514d\u75ab<\/em>\u201d<\/em>\u9aa8\u5e72<\/em>\u201d<\/em>\u7597\u6cd5<\/em><\/h3>\n

\"asco-gi-2026-hanchorbio\"\u6c49\u5eb7\u751f\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/strong>\uff08TPEx\uff1a7827\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u5f00\u53d1\u6b21\u4e16\u4ee3\u80bf\u7624\u4e0e\u81ea\u4f53\u514d\u75ab\u75be\u75c5\u514d\u75ab\u7597\u6cd5\u7684\u5168\u7403\u4e34\u5e8a\u9636\u6bb5\u751f\u6280\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u6b63\u5728\u8fdb\u884c\u4e2d\u7684 HCB101 <\/strong>\u8054<\/strong>\u5408\u6807\u51c6\u6cbb\u7597\uff08<\/strong>SoC<\/strong>\uff09<\/strong>\u65b9\u6848\u7684 Phase 1b\/2a <\/strong>\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\u6570\u636e\uff0c\u5df2\u83b7\u9009 2026 <\/strong>\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u6d88\u5316\u9053\u80bf\u7624\u5927\u4f1a\uff08<\/strong>ASCO GI 2026<\/strong>\uff09<\/strong> \u4ee5\u58c1\u62a5\u5f62\u5f0f\u53d1\u8868\u3002\u8be5\u4f1a\u8bae\u5c06\u4e8e 2026 <\/strong>\u5e74<\/strong> 1 <\/strong>\u6708<\/strong> 8\u201310 <\/strong>\u65e5<\/strong> \u5728\u7f8e\u56fd\u65e7\u91d1\u5c71\u4e3e\u884c\u3002<\/p>\n

\u672c\u6b21\u83b7\u9009\u4e4b\u6458\u8981\uff08Abstract ID<\/strong>\uff1a<\/strong>372<\/strong>\uff09\u663e\u793a\uff0c\u5728\u4e00\u7ebf\u6cbb\u7597\u540e\u5931\u8d25\u540e\u7684\u665a\u671f\u80c3\u817a\u764c\u60a3\u8005\u4e2d\uff0cHCB101 <\/strong>\u8054\u5408<\/strong>ramucirumab <\/strong>\u4e0e<\/strong> paclitaxel<\/strong> \u5c55\u73b0\u51fa\u660e\u786e\u7684\u5242\u91cf\u4f9d<\/strong>\u8d56\u6027\u6297\u80bf\u7624\u6d3b\u6027<\/strong>\uff0c\u4e14\u6574\u4f53\u5b89\u5168\u6027\u53ef\u63a7\u3002\u5c3d\u7ba1\u672c\u7814\u7a76\u4ecd\u5c5e\u65e9\u671f\u4e34\u5e8a\u9636\u6bb5\uff0c\u4f46\u76ee\u524d\u89c2\u5bdf\u5230\u7684\u80bf\u7624\u53cd\u5e94\u7387\u4e0e\u80bf\u7624\u7f29\u5c0f\u5e45\u5ea6\uff0c\u5728\u65e2\u5f80\u4e8c\u7ebf\u6807\u51c6\u6cbb\u7597\u7814\u7a76\u4e2d\u5904\u4e8e\u8f83\u9ad8\u6c34\u5e73\uff0c\u5305\u62ec\u5168\u7403 RAINBOW <\/strong>\u8bd5\u9a8c\uff08<\/strong>NCT01170663<\/strong>\uff09<\/strong> \u53ca RAINBOW-Asia <\/strong>\u8bd5\u9a8c\uff08<\/strong>NCT01939899<\/strong>\uff09<\/strong> \u6240\u62a5\u9053\u7684\u7ed3\u679c\uff0c\u4e3a\u4ee5 HCB101 <\/strong>\u4e3a<\/strong>\u6838\u5fc3\u7684\u8054\u5408<\/strong>\u6cbb\u7597<\/strong>\u65b9\u6848 \u6301\u7eed\u63a8\u8fdb\u4e34\u5e8a\u5f00\u53d1\u63d0\u4f9b\u4e86\u652f\u6301\u4f9d\u636e\u3002<\/p>\n

\u4e8c\u7ebf\u80c3\u764c\u662f\u5168\u7403\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u5b9a\u4e49\u6e05\u6670\u3001\u6cbb\u7597\u8def\u5f84\u6210\u719f\u7684\u6807\u51c6\u6cbb\u7597\u573a\u666f\uff0c\u4f46\u6574\u4f53\u7597\u6548\u4ecd\u5b58\u5728\u8f83\u5927\u63d0\u5347\u7a7a\u95f4\u3002HCB101 <\/strong>\u7684\u8bbe\u8ba1<\/strong>\u601d\u8def\u5e76\u975e\u6539\u53d8\u65e2\u6709\u6cbb\u7597\u6846\u67b6\uff0c\u800c\u662f\u5bf9\u5176\u8fdb\u884c\u300c\u8865\u5f3a\u800c\u975e\u98a0\u8986\u300d<\/strong>: <\/strong>\u5728\u4e0d\u5f71\u54cd\u6807\u51c6\u7ed9\u836f\u5242\u91cf\u3001\u5b89\u5168\u6027\u9884\u671f\u53ca\u65e5\u5e38\u4e34\u5e8a\u64cd\u4f5c\u6d41\u7a0b\u7684\u524d\u63d0\u4e0b\uff0c\u5f15\u5165\u5148\u5929\u514d\u75ab\u8c03\u63a7\u673a\u5236\uff0c\u4f7f\u5176\u80fd\u591f\u987a\u5229\u878d\u5165\u73b0\u6709\u6cbb\u7597\u4f53\u7cfb\u3002<\/p>\n

ASCO GI 2026 <\/strong>\u53d1\u8868\u4fe1\u606f<\/strong><\/p>\n

    \n
  • \u58c1\u62a5\u6807\u9898<\/strong>\uff1aDose-Dependent Antitumor Activity of HCB101 Plus Ramucirumab and Paclitaxel in Previously Treated Gastric Cancer<\/li>\n
  • \u6458\u8981\u7f16\u53f7<\/strong>\uff1a372<\/li>\n
  • \u53d1\u8868\u8005<\/strong>\uff1a\u9646\u82f1\u660e \u535a\u58eb<\/li>\n
  • \u65e5\u671f\uff0f\u65f6\u95f4<\/strong>\uff1a2026 \u5e74 1 \u6708 8 \u65e5\uff5c\u4e0a\u5348 11:30 \u2013 \u4e0b\u5348 1:00 (PDT)<\/li>\n<\/ul>\n

    \u66f4\u591a\u6765\u81ea\u6b64\u9879 Phase 1b\/2a \u4e34\u5e8a\u8bd5\u9a8c\u7684\u5206\u6790\u7ed3\u679c\u4e0e\u6570\u636e\uff0c\u5c06\u4e8e ASCO GI 2026 \u58c1\u62a5\u4ea4\u6d41\u671f\u95f4\u540c\u6b65\u516c\u5e03\u3002<\/p>\n

    \u6c49\u5eb7\u751f\u6280\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98 \u5218\u4e16\u9ad8<\/strong> \u535a\u58eb<\/strong> \u8868\u793a\uff1a<\/p>\n

    \u300c\u591a\u5e74\u6765\uff0cCD47\u2013SIRP\u03b1\u901a\u8def\u5728\u80bf\u7624\u514d\u75ab\u9003\u9038\u4e2d\u7684\u4f5c\u7528\u5df2\u88ab\u5e7f\u6cdb\u8ba4\u77e5\uff0c\u4f46\u5c06\u8fd9\u4e00\u751f\u7269\u5b66\u673a\u5236\u6210\u529f\u8f6c\u5316\u4e3a\u53ef\u884c\u7684\u4e34\u5e8a\u6cbb\u7597\u65b9\u6848\uff0c\u4e00\u76f4\u9762\u4e34\u8f83\u5927\u6311\u6218\u3002HCB101 \u81ea\u8bbe\u8ba1\u4e4b\u521d\u5373\u7ed3\u5408 AI \u6280\u672f\uff0c\u9488\u5bf9\u8fd9\u4e00\u6838\u5fc3\u95ee\u9898\u8fdb\u884c\u7cfb\u7edf\u6027\u4f18\u5316\u3002\u6211\u4eec\u5de5\u7a0b\u5316\u8bbe\u8ba1\u7684SIRP\u03b1 \u5206\u5b50\u663e\u8457\u589e\u5f3a\u4e86\u5176\u4e0e\u80bf\u7624\u7ec6\u80deCD47\u7684 \u7ed3\u5408\u4eb2\u548c\u529b\uff0c\u540c\u65f6\u6709\u6548\u89c4\u907f\u514d\u4e86\u65e9\u671f\u7597\u6cd5\u6cd5\u4e2d\u5e38\u89c1\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u9650\u5236\u3002\u5728\u4e0e\u5df2\u88ab\u4e34\u5e8a\u548c\u5546\u4e1a\u5145\u5206\u9a8c\u8bc1\u7684\u4e8c\u7ebf\u80c3\u764c\u6807\u51c6\u6cbb\u7597\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u53cd\u590d\u89c2\u5bdf\u5230\u6e05\u6670\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5c55\u793a\u4e86\u5148\u5929\u514d\u75ab\u8c03\u63a7\u4f5c\u4e3a\u300e\u7ec4\u5408\u53cb\u597d\u578b\u300f\u514d\u75ab\u6cbb\u7597\u9aa8\u5e72\u7684\u6f5c\u5728\u4ef7\u503c\u3002\u300d<\/p>\n

    \u4ee5\u300c\u9aa8\u5e72<\/strong> (backbone) <\/strong>\u7597\u6cd5\u300d\u4e3a\u6838\u5fc3\u7684\u673a\u8f6c\u8bbe\u8ba1\u903b\u8f91<\/strong><\/p>\n

    HCB101<\/strong> \u662f\u4e00\u6b3e\u5de5\u7a0b\u5316 SIRP\u03b1\u2013<\/strong>IgG4 Fc <\/strong>\u878d\u5408\u86cb\u767d<\/strong>\uff0c\u53ef\u9009\u62e9\u6027\u963b\u65ad CD47\u2013SIRP\u03b1 <\/strong>\u5148\u5929\u514d\u75ab\u68c0\u67e5\u70b9<\/strong>\uff0c\u6062\u590d\u5de8\u566c\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\uff0c\u540c\u65f6\u5c06\u7ea2\u8840\u7403\u7ed3\u5408\u98ce\u9669\u964d\u81f3\u6700\u4f4e\uff0c\u4f7f\u5176\u5728\u8054\u5408\u6cbb\u7597\u4e2d\u5177\u5907\u826f\u597d\u7684\u5b89\u5168\u6027\u57fa\u7840\u3002<\/p>\n

    \u5728\u4e8c\u7ebf\u80c3\u764c\u6807\u51c6\u6cbb\u7597\u4e2d\uff0cramucirumab<\/strong> \u6709\u52a9\u4e8e\u6539\u5584\u80bf\u7624\u8840\u7ba1\u7ed3\u6784\u5e76\u7f13\u89e3 VEGF \u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\uff0c\u800c paclitaxel<\/strong> \u5219\u53ef\u8bf1\u5bfc\u514d\u75ab\u539f\u6027\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u5e76\u4fc3\u8fdb\u6297\u539f\u91ca\u653e\u3002\u4e09\u8005\u8054\u7528\u4f7f \u5148\u5929\u514d\u75ab<\/strong>\u6fc0\u6d3b<\/strong>\u673a\u5236\u80fd\u591f\u81ea\u7136<\/strong>\u5d4c\u5165<\/strong>\u65e2\u6709\u6807\u51c6\u6cbb\u7597<\/strong>\u4f53\u7cfb\uff0c\u5f62\u6210\u517c\u5177\u751f\u7269\u5b66\u5408\u7406\u6027\u4e0e\u4e34\u5e8a\u53ef\u64cd\u4f5c\u6027\u7684\u6297\u80bf\u7624\u7b56\u7565\u3002<\/p>\n

    \u6c49\u5eb7\u751f\u6280\u96c6\u56e2\u603b\u88c1\u517c\u9996\u5e2d\u533b\u5b66\u5b98\u3001\u4ee5\u53ca\u7f8e\u56fd\u5b50\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98\u9646\u82f1\u660e<\/strong> \u535a\u58eb<\/strong> \u8865\u5145\u8868\u793a\uff1a<\/p>\n

    \u300c\u4e8c\u7ebf\u80c3\u764c\u5177\u5907\u660e\u786e\u7684\u4e34\u5e8a\u57fa\u51c6\u548c\u5e7f\u6cdb\u5e94\u7528\u7684\u6cbb\u7597\u6d41\u7a0b\u3002\u672c\u6b21\u65e9\u671f\u7814\u7a76\u4e2d\uff0c\u6700\u503c\u5f97\u5173\u6ce8\u7684\u4e0d\u4ec5\u662f HCB101 \u8054\u5408 ramucirumab \u4e0e paclitaxel \u6240\u5c55\u73b0\u7684\u80bf\u7624\u53cd\u5e94\u6df1\u5ea6\u4e0e\u9891\u7387\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u7597\u6548\u662f\u5728\u4e0d\u727a\u7272\u65e2\u6709\u6cbb\u7597\u5b89\u5168\u6027<\/strong>\u548c\u771f\u5b9e\u4e16\u754c\u4e34\u5e8a\u53ef\u884c\u6027<\/strong>\u7684\u524d\u63d0\u4e0b\u5b9e\u73b0\u7684\u3002\u6211\u671f\u5f85\u5728 ASCO GI \u53d1\u8868\u8fd9\u4e9b\u6210\u679c\uff0c\u5e76\u4e0e\u4e34\u5e8a\u540c\u884c\u63a2\u8ba8\u5148\u5929\u514d\u75ab\u673a\u5236\u5728\u80c3\u764c\u6cbb\u7597\u4e2d\u7684\u66f4\u5e7f\u6cdb\u5e94\u7528\u524d\u666f\u3002\u300d<\/p>\n

    \u5173\u4e8e<\/strong> HCB101<\/strong><\/p>\n

    HCB101<\/strong> \u662f\u57fa\u4e8e\u6c49\u5eb7\u751f\u6280 \u81ea\u4e3bFBDB\u2122 <\/strong>\u5e73\u53f0<\/strong> \u7406\u6027\u8bbe\u8ba1\u7684 SIRP\u03b1\u2013IgG4 Fc <\/strong>\u878d\u5408\u86cb\u767d<\/strong>\uff0c\u65e8\u5728\u9009\u62e9\u6027\u963b\u65ad CD47\u2013SIRP\u03b1 \u5148\u5929\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u540c\u65f6\uff0c\u6700\u5927\u7a0b\u5ea6\u964d\u4f4e\u8840\u6db2\u5b66\u6bd2\u6027\u3002\u4e0e\u65e9\u671f\u6297 CD47 \u7597\u6cd5\u4e0d\u540c\uff0cHCB101 \u7684\u8bbe\u8ba1\u80fd\u5728\u4fdd\u7559\u5de8\u566c\u7ec6\u80de\u6297\u80bf\u7624\u6d3b\u6027\u7684\u540c\u65f6\uff0c\u663e\u8457\u51cf\u5c11\u5bf9\u7ea2\u8840\u7403\u4e0e\u8840\u5c0f\u677f\u7684\u975e\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u4ece\u800c\u7a81\u7834\u4e86\u8be5\u9776\u70b9\u8fc7\u5f80\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u4e3b\u8981\u9650\u5236\u3002<\/p>\n

    \u6b64\u5916\uff0cHCB101 \u5728\u8bbe\u8ba1\u4e4b\u521d\u5373\u4ee5\u8054\u5408\u6cbb\u7597<\/strong>\u4e3a\u6838\u5fc3\u76ee\u6807\uff0c\u5176\u5b89\u5168\u6027\u3001\u53d7\u4f53\u5360\u636e\u7387\u53ca\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u6027\uff0c\u652f\u6301\u5176\u5728\u4e0d\u5e72\u6270\u6807\u51c6\u5242\u91cf\u3001\u5b89\u5168\u6027\u9884\u671f\u53ca\u4e34\u5e8a\u6d41\u7a0b\u7684\u524d\u63d0\u4e0b\uff0c\u4e0e\u6210\u719f\u80bf\u7624\u6cbb\u7597\u65b9\u6848\u534f\u540c\u5e94\u7528\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0cHCB101 \u5df2\u5728\u5355\u836f\u53ca\u8054\u5408\u6cbb\u7597\u7684\u4e34\u5e8a\u548c\u8f6c\u5316\u7814\u7a76\u4e2d\uff0c\u5c55\u73b0\u51fa\u4e00\u81f4\u7684\u9776\u70b9\u7ed3\u5408\u80fd\u529b\u548c\u65e9\u671f\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u5728\u8fc7\u53bb\u88ab\u8ba4\u4e3a\u5bf9 CD47 \u9776\u5411\u7597\u6cd5\u5177\u6311\u6218\u6027\u7684\u80bf\u7624\u7c7b\u578b\u4e2d\u3002\u8fd9\u4e9b\u7279\u6027\u4f7f HCB101 \u6210\u4e3a\u4e00\u6b3e\u5177\u5dee\u5f02\u5316\u6f5c\u529b\u7684\u5de8\u566c\u7ec6\u80de\u68c0\u67e5\u70b9\u9aa8\u5e72\u7597\u6cd5<\/strong>\uff0c\u53ef\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5b9e\u8bc1\u6210\u719f\u7684\u5b9e\u4f53\u7624\u4e0e\u8840\u6db2\u80bf\u7624\u6cbb\u7597\u6846\u67b6\u4e2d\u3002<\/p>\n

    \u5173\u4e8e\u6c49\u5eb7\u751f\u6280<\/strong><\/p>\n

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